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research article

Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics

Chollet, A.
•
Turcatti, G.  
1999
Journal of Computer-Aided Molecular Design

G protein-coupled receptors (GPCR) represent a large family of drug targets for which there is no high-resolution structural information. In order to understand the mechanisms of ligand recognition and receptor activation, there is a strong need for novel biophysical methods. In this perspective we provide an overview of recent experimental approaches used to explore the molecular architecture and dynamics of GPCR and their interactions with ligands and G proteins using biophysical, non-crystallographic, methods.

  • Details
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Type
research article
DOI
10.1023/A:1008052002695
Author(s)
Chollet, A.
Turcatti, G.  
Date Issued

1999

Published in
Journal of Computer-Aided Molecular Design
Volume

13

Issue

3

Start page

209

End page

219

Subjects

Electron paramagnetic resonance (EPR)

•

Fluorescence resonance energy transfer (FRET)

•

Ligand-receptor interactions

•

Neurokinin receptors

•

Nonsense suppression mutagenesis

•

Rhodopsin

•

drug

•

guanine nucleotide binding protein

•

drug receptor binding

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
PTCB  
Available on Infoscience
August 14, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/232866
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