Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are Selective alpha-Mannosidase Inhibitors

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K-i=7.4 VM) and selective inhibition of alpha -mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.


Publié dans:
Bioorganic and Medicinal Chemistry Letters, 11, 2489-2493
Année
2001
Mots-clefs:
Laboratoires:




 Notice créée le 2006-06-08, modifiée le 2018-03-17


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