1-Bromo-3,5-bis(trifluoromethyl)benzene: a versatile starting material for organometallic synthesis

1-Bromo-3,5-bis(trifluoromethyl)benzene was selectively prepd. by treatment of 1,3-bis(fluoromethyl)benzene with N,N'-dibromo-5,5-dimethylhydantoin in strongly acidic media. A no. of synthetically useful reactions via 3,5-bis(trifluoromethyl)phenylmagnesium, -lithium, and -copper intermediates were accomplished. [on SciFinder (R)]


Published in:
Chemische Berichte, 129, 2, 233-5
Year:
1996
Keywords:
Note:
CAN 124:288867 25-3 Benzene, Its Derivatives, and Condensed Benzenoid Compounds Institut Chimie Organique,Universite Lausanne,Lausanne-Dorigny,Switz. Journal 0009-2940 written in English. 96-33-3 (Methyl acrylate); 106-95-6 (Allyl bromide); 119-61-9 (Benzophenone); 402-31-3 (1,3-Bis(trifluoromethyl)benzene); 1079-66-9 (Chlorodiphenylphosphine) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of bromobis(trifluoromethyl)benzene as starting material for organometallic synthesis); 328-70-1P (1-Bromo-3,5-bis(trifluoromethyl)benzene) Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of bromobis(trifluoromethyl)benzene as starting material for organometallic synthesis); 349-58-6P (3,5-Bis(trifluoromethyl)phenol); 401-95-6P (3,5-Bis(trifluoromethyl)benzaldehyde); 725-89-3P (3,5-Bis(trifluoromethyl)benzoic acid); 729-81-7P (1,3,5-Tris(trifluoromethyl)benzene); 175136-62-6P; 175650-32-5P (1-Allyl-3,5-bis(trifluoromethyl)benzene); 175650-33-6P; 175650-34-7P; 175650-35-8P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of bromobis(trifluoromethyl)benzene as starting material for organometallic synthesis)
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