a-Fluoro analogs of inflammation inhibiting a-arylpropionic acids

• Published in: Tetrahedron, vol. 52, num. 24, p. 8257-8262
• Publication date: 1996

2-Aryl-2-fluoropropionic acids were prepd. by treatment of either Et a-hydroxycarboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The Me ester of 2-fluoro-2-(4-isobutylphenyl)propionic acid ("a-fluoroibuprofen") was submitted to an enzymic racemate resoln. [on SciFinder (R)]

Keywords: Inflammation inhibitors (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids) ; antiinflammatory fluoro aryl propionic acid prepn; cyanohydrin silyl ether fluorination aminosulfur fluoride; fluorination aminosulfur fluoride hydroxycarboxylate cyanohydrin

Note:

CAN 125:167482

25-17

Benzene, Its Derivatives, and Condensed Benzenoid Compounds

Inst. Chemie,Universite Batiment de Chemie,Lausanne-Dorigny,Switz.

Journal

0040-4020

written in English.

17172-46-2P; 180293-48-5P; 180293-49-6P; 180293-50-9P; 180293-51-0P; 180293-53-2P; 180293-54-3P; 180293-55-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 98-86-2 (Acetophenone); 99-91-2 (p-Chloroacetophenone); 617-35-6 (Ethyl pyruvate); 38861-78-8 (p-Isobutylacetophenone) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids); 32122-08-0P; 59718-00-2P; 60473-29-2P; 74590-67-3P; 95392-12-4P; 100126-96-3P; 122795-14-6P; 180293-46-3P; 180293-47-4P; 180293-52-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids)

Reference

• LSCO-ARTICLE-1996-011

Record created on 2006-03-03, modified on 2016-08-08