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  4. a-Fluoro analogs of inflammation inhibiting a-arylpropionic acids
 
research article

a-Fluoro analogs of inflammation inhibiting a-arylpropionic acids

Schlosser, Manfred  
•
Michel, Dominique
•
Guo, Zhi-wei
Show more
1996
Tetrahedron

2-Aryl-2-fluoropropionic acids were prepd. by treatment of either Et a-hydroxycarboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The Me ester of 2-fluoro-2-(4-isobutylphenyl)propionic acid ("a-fluoroibuprofen") was submitted to an enzymic racemate resoln. [on SciFinder (R)]

  • Details
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Type
research article
DOI
10.1016/0040-4020(96)00411-5
Author(s)
Schlosser, Manfred  
Michel, Dominique
Guo, Zhi-wei
Sih, Charles J.
Date Issued

1996

Published in
Tetrahedron
Volume

52

Issue

24

Start page

8257

End page

8262

Subjects

Inflammation inhibitors (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids)

•

antiinflammatory fluoro aryl propionic acid prepn; cyanohydrin silyl ether fluorination aminosulfur fluoride; fluorination aminosulfur fluoride hydroxycarboxylate cyanohydrin

Note

CAN 125:167482

25-17

Benzene, Its Derivatives, and Condensed Benzenoid Compounds

Inst. Chemie,Universite Batiment de Chemie,Lausanne-Dorigny,Switz.

Journal

written in English.

17172-46-2P; 180293-48-5P; 180293-49-6P; 180293-50-9P; 180293-51-0P; 180293-53-2P; 180293-54-3P; 180293-55-4P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 98-86-2 (Acetophenone); 99-91-2 (p-Chloroacetophenone); 617-35-6 (Ethyl pyruvate); 38861-78-8 (p-Isobutylacetophenone) Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids); 32122-08-0P; 59718-00-2P; 60473-29-2P; 74590-67-3P; 95392-12-4P; 100126-96-3P; 122795-14-6P; 180293-46-3P; 180293-47-4P; 180293-52-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of a-fluoro analogs of inflammation inhibiting a-arylpropionic acids)

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSCO  
Available on Infoscience
March 3, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/226930
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