Journal article

a-Fluoro analogs of inflammation inhibiting a-arylpropionic acids

2-Aryl-2-fluoropropionic acids were prepd. by treatment of either Et a-hydroxycarboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The Me ester of 2-fluoro-2-(4-isobutylphenyl)propionic acid ("a-fluoroibuprofen") was submitted to an enzymic racemate resoln. [on SciFinder (R)]


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