About bases and superbases
A review with 26 refs. on the authors work on metalation by bases and superbases. BuLi requires activation to become capable of abstracting a proton from weakly acidic hydrocarbons like cyclopropanes, simple olefins, or arenes. The addn. of stoichiometric amts. of KOCMe3 is a most effective means of enhancing the rate of a H/metal exchange. Superbasic alkyllithium/K alcoholate mixts. are endowed not only with an unsurpassed reactivity but also with a surprisingly high selectivity as evidenced by series of optionally site-selective arene metalations. [on SciFinder (R)]
Keywords: Metalation (hydrogen/metal exchange by bases and superbases); Bases Role: RCT (Reactant) ; RACT (Reactant or reagent) (hydrogen/metal exchange by bases and superbases); Bases Role: RCT (Reactant) ; RACT (Reactant or reagent) (super-; hydrogen/metal exchan ; review base superbase metalation
Physical Organic Chemistry
Institut Chimie Organique,Universite Lausanne,Lausanne,Switz.
Journal; General Review
written in English.
Record created on 2006-03-03, modified on 2016-08-08