Journal article

The Diels-Alder route to trifluoromethyl-substituted carbo- and heterocycles

Starting with 1,1,1-trifluoroacetone, 3-(trifluoromethyl)-1-(trimethylsilyloxy)-1,3-butadiene has been prepd. as a mixt. of (Z) and (E) isomers. The diene undergoes [4 + 2] cycloaddn. reactions with a variety of dienophiles affording trifluoromethyl-substituted carbocyclic and heterocyclic compds. in yields ranging from moderate to good. [on SciFinder (R)]


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