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research article
Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells
2005
A review. New, improved phenotypes. Somatic hypermutation in immune cells can be used for the fast directed evolution of proteins other than Igs (e.g., autofluorescent proteins). The target gene is inserted into the genome of activated B lymphocytes where it is mutated. Cells expressing a desired phenotype are selected and subjected to further evolution cycles to accumulate beneficial mutations. [on SciFinder (R)]
Type
research article
Web of Science ID
WOS:000229171800003
Authors
Publication date
2005
Published in
Volume
6
Issue
5
Start page
804
End page
806
Peer reviewed
REVIEWED
Available on Infoscience
February 27, 2006
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