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research article
Protein-Functionalized Polymer Brushes
2005
A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subsequent O6-benzylguanine (BG) functionalization. The BG-functionalized brushes are used to chemoselectively immobilize O6-alkylguanine-DNA-alkyltransferase (AGT) fusion proteins with a defined orientation and surface d. These protein-modified polymer brushes are attractive candidates for the development of protein microarrays. [on SciFinder (R)]
Type
research article
Web of Science ID
WOS:000229138900056
Authors
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Sielaff, India
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Sielaff, I.
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Publication date
2005
Published in
Volume
6
Issue
3
Start page
1602
End page
1607
Peer reviewed
REVIEWED
Available on Infoscience
February 27, 2006
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