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research article
Inter- and intramolecular domain interactions of the catalase-peroxidase KatG from M. tuberculosis
2001
The inter- and intramol. interactions between the different domains of the catalase-peroxidase KatG from Mycobacterium tuberculosis were analyzed using the two-hybrid assay. It was shown that the dimerization of the enzyme is due to a strong interaction of the first 99 amino acids of the N-terminal domain whereas the C-terminal domain does not play a role in the dimerization. In addn., an intramol. interaction between the N- and C-terminal domains was detected which might play a functional role in the mechanism of the enzyme. [on SciFinder (R)]
Type
research article
Web of Science ID
WOS:000172757500025
Authors
Publication date
2001
Published in
Volume
509
Issue
2
Start page
272
End page
276
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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