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research article
Mechanistic Studies of the Oxidation of Isoniazid by the Catalase Peroxidase from Mycobacterium tuberculosis
The enzymic oxidn. of isoniazid by the catalase-peroxidase of Mycobacterium tuberculosi was studied. The reaction products suggest two reaction pathways involving both electrophilic and radical species. Labeling expts. are consistent with a reaction mechanism involving the formation of an acyldiimide intermediate followed by decompn. to the corresponding aldehyde and peracid. The results suggest that isoniazid is oxidized by the catalase-peroxidase to a reactive species that may act by inactivating an essential enzyme of M. tuberculosis. [on SciFinder (R)]
Type
research article
Authors
Publication date
1994
Published in
Volume
116
Issue
16
Start page
7425
End page
6
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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