Triple helix binding of oligodeoxyribonucleotides containing 8-oxo-2'-deoxyadenosine

Formation of a triple helix between an oligodeoxyribonucleotide contg. 8-oxo-2'-deoxyadenosine and a DNA duplex target was studied as a function of pH. Above pH 7.4, the triple helix with the 8-oxo-2'-deoxyadenosine was more stable than the complex with an analogous oligodeoxyribonucleotide contg. deoxycytidine instead of 8-oxo-2'-deoxyadenosine. [on SciFinder (R)]


Published in:
Nucleosides & Nucleotides, 12, 2, 237-43
Year:
1993
Laboratories:




 Record created 2006-02-27, last modified 2018-03-17


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