New multicomponent capsules for immunoisolation

A new generation of microcapsules based on the use of oligomers which participate in polyelectrolyte complexation reactions has been developed. These freeze-thaw stable capsules have been applied as a bioartificial pancreas and have resulted in normoglycemia for periods of six months in concordant xenotransplantations. The new chem. permits the control of permeability and mech. properties over a wide range and can be adapted both to microcapsule and hollow fiber geometries rendering it a robust tool for encapsulation in general. Methods, and metrics, for the characterization of the mech. properties and permeability of microcapsules are presented. [on SciFinder (R)]

Published in:
Annals of the New York Academy of Sciences, 875, Bioartificial Organs II, 135-145

 Record created 2006-02-27, last modified 2018-03-17

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