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research article
Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets
Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat). [on SciFinder (R)]
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Type
research article
Authors
Hill, R. S.
•
Cruise, G. M.
•
Hager, S. R.
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Lamberti, F. V.
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Yu, X.
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Garufis, C. L.
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Yu, Y.
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Mundwiler, K. E.
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Cole, J. F.
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Publication date
1997
Published in
Volume
831
Start page
332
End page
43
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006