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conference paper
Membrane receptor proteins at interfaces for bioanalytics in the micro- and nanometer range
2001
Micro Total Analysis Systems 2001
A review. Cell-based assays are the predominant means of assessing activation of ionotropic receptors and G protein-coupled receptors (GPCRs), but are limited by their inherent complexity. Here we present an approach to immobilize receptors stably and with defined orientation in microarrays on sensor surfaces. Using optical and elec. methods we were able to follow ligand binding, receptor activation and receptor deactivation. Our findings are a novel approach for functional screening of pharmacol. interesting receptor proteins in high d. format. [on SciFinder (R)]
Type
conference paper
Authors
Publication date
2001
Published in
Micro Total Analysis Systems 2001
Start page
242
End page
243
Peer reviewed
REVIEWED
EPFL units
Event name | Event place | Event date |
Monterey, CA, United States | Oct. 21-25, 2001 | |
Available on Infoscience
February 27, 2006
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