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  4. Sulfur-bearing lipids for the covalent attachment of supported lipid bilayers to gold surfaces: a detailed characterization and analysis
 
research article

Sulfur-bearing lipids for the covalent attachment of supported lipid bilayers to gold surfaces: a detailed characterization and analysis

Duschl, Claus
•
Liley, Martha
•
Lang, Holger
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1996
Materials Science and Engineering C

In a recent paper, a new class of synthetic lipids, which self-assemble to form monolayers on gold surfaces, was introduced. The addn. of a monolayer of phospholipids to these layers results in robust supported lipid bilayers designed to reconstitute transmembrane proteins. This paper presents a detailed characterization of the monolayers and bilayers formed by these lipids and assesses their ability for the incorporation of membrane-spanning proteins. Film balance methods, electron microscopy, surface plasmon resonance, Fourier transform IR measurements and Raman spectroscopy show the feasibility of this concept. However, further modifications to improve the thiolipids are necessary. A new strategy for the formation of laterally structured supported lipid bilayers is discussed and initial results are presented. [on SciFinder (R)]

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Type
research article
DOI
10.1016/0928-4931(95)00123-9
Web of Science ID

WOS:A1996UG54900002

Author(s)
Duschl, Claus
Liley, Martha
Lang, Holger
Ghandi, Azin
Zakeeruddin, Shaik M.
Stahlberg, Henning  orcid-logo
Dubochet, Jacques
Nemetz, Axel
Knoll, Wolfgang
Vogel, Horst  
Date Issued

1996

Published in
Materials Science and Engineering C
Volume

4

Issue

1

Start page

7

End page

18

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCPPM  
LBEM  
Available on Infoscience
February 27, 2006
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/226294
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