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conference paper
All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor
2000
Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000
Comprehensive and cGMP suitable bioprocess monitoring is still a challenge in microbial fermn. and cell culture process development. This paper discusses the exploitation of in-situ mid-IR spectroscopy in combination with partial least-squares anal. to monitor carbohydrate, amino acid, org. acid, pH, temp., and biomass content of Saccharomyces Cerevisiae, Phaffia rhodozyma, and CHO cell cultures. Reliability of the monitored values will be discussed for potential application in cGMP environments along with case studies to increase the productivity by using the information for controlling the processes. [on SciFinder (R)]
Type
conference paper
Web of Science ID
WOS:000087246101087
Authors
Publication date
2000
Published in
Book of Abstracts, 219th ACS National Meeting, San Francisco, CA, March 26-30, 2000
Start page
BIOT
End page
363
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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