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In the ribosomal biosynthesis of proteins, the aminoacylated t-RNAs serve as carriers of the amino acids. A total synthesis of these biol. key-compds. would allow the site-specific incorporation of modifications within the t-RNA and attachment of any desired amino acid. Such analogs are useful tools for structural and functional studies, and for the incorporation of unnatural amino acids into proteins. Our retrosynthetic scheme for the prepn. of aminoacylated t-RNAs includes the synthesis of truncated t-RNAs, the synthesis of aminoacylated RNA-fragments, and their subsequent ligation. In this article, we present our approaches toward the realization of these three tasks. [on SciFinder (R)]
Type
research article
Authors
Publication date
2001
Published in
Volume
55
Issue
1-2
Start page
60
End page
64
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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