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research article
NMR study of the p-DNA duplex [(4'->2')-3'-desoxyribopyranosyl-(m5CGDDTTm5CG)2] and comparison with its p-RNA analogue
2001
The detn. of the soln. structure of small non-natural oligopeptides and oligonucleotides by NMR, which is one of the main research topics of our group, is illustrated on the example of an 8-mer p-DNA duplex. P-DNA, the 3'-desoxy analog of p-RNA, forms an highly selective pairing system but its pairing strength is less than that of analogous p-RNA sequences. The NMR study reveals that the backbone of p-DNA corresponds more closely to the conformation predicted for pentapyranose nucleic acids by qual. conformational anal. than p-RNA. [on SciFinder (R)]
Type
research article
Authors
Publication date
2001
Published in
Volume
55
Issue
10
Start page
852
End page
855
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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