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research article
The eight stereoisomers of LNA (locked nucleic acid): a remarkable family of strong RNA binding molecules
The authors evaluated the RNA binding of all eight possible stereoisomers of LNA. Synthesis of "a-l-xylo-LNA" has been accomplished and the remaining four stereoisomers, all enantiomers of the four synthesized diastereoisomers, are indirectly evaluated by hybridization studies. The remarkable binding affinities and specificities obtained for LNA and a-l-LNA, both in a fully and in a partly modified context, establish these mols. as unique nucleic acid mimics. A strong impetus for this research has been, and continues to be, the therapeutic promises of the antisense strategy. [on SciFinder (R)]
Type
research article
Authors
Rajwanshi, Vivek K.
•
Hakansson, Anders E.
•
Sorensen, Mads D.
•
•
Singh, Sanjay K.
•
Kumar, Ravindra
•
Nielsen, Poul
•
Wengel, Jesper
Publication date
2000
Published in
Volume
39
Issue
9
Start page
1656
End page
1659
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 27, 2006
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