A Highly Enantio-Selective Hexitol Nucleic Acid Template for Nonenzymic Oligoguanylate Synthesis

The authors compare the enantiomeric cross-inhibition of D- and L-guanosine 5'-phosphoro-2-methyl-imidazole (I) polymn. on C10 (RNA), dC10 (DNA), or hC10 (hexitol nucleic acid) (II). RNA or DNA templates catalyze efficient oligomerization of D-I, with a strong enantiomeric cross-inhibition by L-I, but II shows efficient oligomerization of D-I with a less sever cross-inhibition, resulting in G6-9 polymers, thus showing that efficient selection of one optical isomer from a racemic mixt. of nucleotides during nonenzymic oligo-nucleotide synthesis on an analog of a nucleic acid template is possible, which may be of relevance to prebiotic conditions. [on SciFinder (R)]

Published in:
Journal of the American Chemical Society, 121, 5, 1108-1109

 Record created 2006-02-27, last modified 2018-01-27

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