This study is concerned with the effects of applying selective pulses to systems with strong 2nd-order scalar couplings in isotropic phase, where different transitions (rs) are assocd. with different transition matrix elements F(rs)+. Two unusual features can be distinguished: the nutation angle (flip angle) depends on the matrix element of the irradiated transition (rs), and, in contrast to the behavior of an isolated spin-1/2 system, the norm of the three single-transition operators [Ix(rs), Iy(rs), Iz(rs)] assocd. with the fictitious spin-1/2 space of the irradiated transition (rs) is generally not conserved. It is necessary to consider the single-transition operators [I3x(rp), Iy(rp), Iz(rp)] and [Ix(sq), Iy(sq), Iz(sq)] assocd. with all connected transitions (rp) and (sq) that share a common energy level r or s with the irradiated transition (rs). If the pulse applied to the (rs) transition is sufficiently selective, the transverse components Ix(rp), Iy(rp), Ix(sq), and Iy(sq) can be neglected, since their expectation values remain equal to zero after application of a selective pulse to the (rs) transition, but the longitudinal components Iz(rp) and Iz(sq) acquire nonvanishing expectation values. When the selective pulse affects several transitions simultaneously, the response varies from one transition to another, depending on the matrix elements and the connectivities. These effects manifest themselves in unusual amplitudes and phases of signals excited by selective pulses, in particular in selective two-dimensional correlation spectra. [on SciFinder (R)]