Preparation of (ethylene)-(propylene)-triaminepentaacetic acid derivatives for use in the production of pharmaceutical agents
The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.
56290306
Alternative title(s) : (de) (ethylene)-(propylene)-triaminopentaessigsäure derivate, verfahren zu ihrer herstellung und ihre verwendung in der herstellung pharmazeutischer wirkstoffe (fr) Derives d'acide ethylene propylene triamino-pentaacetique, un procede de production correspondant, et leur utilisation dans la production d'agents pharmaceutiques (en) (ethylene)-(propylene)-triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
Patent number | Country code | Kind code | Date issued |
US2004258620 | US | A1 | 2004-12-23 |
JP2004534808 | JP | A | 2004-11-18 |
EP1397339 | EP | A1 | 2004-03-17 |
US2003194371 | US | A1 | 2003-10-16 |
PE03692003 | PE | A1 | 2003-05-21 |
DE10133435 | DE | A1 | 2003-02-06 |
EP1277728 | EP | A1 | 2003-01-22 |
WO03000647 | WO | A1 | 2003-01-03 |