Pseudo-prolines (Psi Pro): direct insertion of Psi Pro systems into cysteine containing peptides

The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (TPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure-activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys]*CsA. (C) 2002 Elsevier Science Ltd. All rights reserved.


Published in:
Tetrahedron Lett., 43, 24, 4389-4390
Year:
2002
ISSN:
0040-4039
Other identifiers:
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


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