Synthesis of biotinylated glycosulfopeptides by chemoselective ligation

Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential role in modulation of biol. activity, protein folding and cellular communication. Here, a novel chem. approach for the synthesis of biotinylated glycosulfopeptides is described based on a combination of acid labile protecting groups, highly acid sensitive resins and two orthogonal chemoselective ligation reactions. [on SciFinder (R)]


Published in:
Tetrahedron Letters, 42, 12, 2297-2299
Year:
2001
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


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