Loading...
conference paper
The dual role of functional pseudo-prolines for the design of novel SH3 ligands
2001
Peptides 2000, Proceedings of the European Peptide Symposium, 26th, Montpellier, France, Sept. 10-15, 2000
Pseudo-proline building blocks exert a dual functionality in enhancing and stabilizing the relevant polyproline II (PPII) conformation and increasing and optimizing van der Waals contacts and hydrogen bonding to the receptor mols. thus modifying affinity and specificity. They are highly useful in studying ligand recognition mediated by Src homol. 3 domains essential in cellular regulation and protein-protein interactions. The 2-C substituents promote the induction of the required PPII helix and allow for optimal complementation of the SH3 topog. [on SciFinder (R)]
Type
conference paper
Authors
Grell, Daniel
•
Tatsu, Yoshiro
•
Durieux, Patricia
•
Fernandez, Jimena
•
Kardinal, Christian
•
Feller, Stephan
•
Publication date
2001
Published in
Peptides 2000, Proceedings of the European Peptide Symposium, 26th, Montpellier, France, Sept. 10-15, 2000
Start page
75
End page
76
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
Use this identifier to reference this record