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research article
Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligands
Pseudoproline-contg. peptide MeCO-Pro-Pro-Pro-Xaa-Pro-Val-Xaa-Pro-Pro-Pro-Pro-OH [Xaa = Ser(yProPh,H) = 2(S)-phenyloxazolidinyl-4-carboxylate] was synthesized and its conformation was examd. by CD spectroscopy. Its inhibition of the Grb2-SH3 domain was tested. [on SciFinder (R)]
Type
research article
Authors
•
Grell, Daniel
•
Tatsu, Yoshiro
•
Durieux, Patricia
•
Fernandez-Carneado, Jimena
•
Hengst, Beatrice
•
Kardinal, Christian
•
Feller, Stephan
Publication date
2001
Published in
Volume
40
Issue
15
Start page
2844
End page
2848
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
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