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research article
Hydrazinolysis of Dde: Complete orthogonality with Aloc protecting groups
1998
Hydrazinolysis of Dde group is troublesome in the presence of Aloc protected peptides. We elucidate that reduction of the Aloc double bond occurs both in solution and on solid support preventing the subsequent Aloc deprotection and resulting in mixtures difficult to purify. We report here that addition of allyl alcohol as scavenger circumvents this side reaction and provides a complete orthogonality between Dde and Aloc in solution and solid phase peptide synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.
Type
research article
Authors
Publication date
1998
Published in
Volume
39
Issue
10
Start page
1175
End page
1178
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
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