POLYETHYLENE-GLYCOL BOUND BENZYL-DERIVATIVES AND FLUORENYL-DERIVATIVES AS SOLUBILIZING SIDE-CHAIN PROTECTING GROUPS IN PEPTIDE-SYNTHESIS

The covalent attachment of polyethylene glycol (PEG) to commonly used protecting groups and their use in peptide synthesis was examined. PEG bound to fluorenyl- and benzyl- type side chain protection for Lys and Glu results in increased solubility of hydrophobic peptides due to a distruption of beta-sheet conformations. PEG-protected peptides can be subject to HPLC purification and further used in convergent strategies for the synthesis of large peptides.


Published in:
Tetrahedron Lett., 35, 7, 1039-1042
Year:
1994
ISSN:
0040-4039
Laboratories:




 Record created 2006-02-09, last modified 2018-01-27


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)