POLYETHYLENE-GLYCOL BOUND BENZYL-DERIVATIVES AND FLUORENYL-DERIVATIVES AS SOLUBILIZING SIDE-CHAIN PROTECTING GROUPS IN PEPTIDE-SYNTHESIS
The covalent attachment of polyethylene glycol (PEG) to commonly used protecting groups and their use in peptide synthesis was examined. PEG bound to fluorenyl- and benzyl- type side chain protection for Lys and Glu results in increased solubility of hydrophobic peptides due to a distruption of beta-sheet conformations. PEG-protected peptides can be subject to HPLC purification and further used in convergent strategies for the synthesis of large peptides.
Record created on 2006-02-09, modified on 2016-08-08