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research article
POLYETHYLENE-GLYCOL BOUND BENZYL-DERIVATIVES AND FLUORENYL-DERIVATIVES AS SOLUBILIZING SIDE-CHAIN PROTECTING GROUPS IN PEPTIDE-SYNTHESIS
1994
The covalent attachment of polyethylene glycol (PEG) to commonly used protecting groups and their use in peptide synthesis was examined. PEG bound to fluorenyl- and benzyl- type side chain protection for Lys and Glu results in increased solubility of hydrophobic peptides due to a distruption of beta-sheet conformations. PEG-protected peptides can be subject to HPLC purification and further used in convergent strategies for the synthesis of large peptides.
Type
research article
Authors
Publication date
1994
Published in
Volume
35
Issue
7
Start page
1039
End page
1042
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
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