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research article
Synthesis of antiparallel 4a-helix bundle TASP by chemoselective ligation
The use of chemoselective ligation methods and orthogonal protection techniques allows access to Template-Assembled Synthetic Protein (TASP) mols. exhibiting a large variety of packing topologies. This is demonstrated for the synthesis of an antiparallel 4a-helical bundle TASP by condensing amphiphilic peptide blocks, contg. aldehyde functions at the C- or N-terminus, to a selectively addressable topol. template via oxime bond formation. The resulting antiparallel 4a-helix TASP is obtained in high yield and shows a template-induced helical conformation. [on SciFinder (R)]
Type
research article
Authors
Publication date
1994
Published in
Volume
1
Issue
1
Start page
9
End page
16
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
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