Template-Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn-Inducing Mimics
The 8-amino-5,6,7,8-tetrahydronaphth-2-oic acid (1), 8-(aminomethyl)-5,6,7,8-tetrahydronaphth-2-oic acid (2), and 8-(aminomethyl)naphth-2-oic acid (3) were synthesized in their protected forms as turn-inducing dipeptide mimics.Two of them (2 and 3) were incorporated into a novel type of cyclic, peptide-based structures (see 21 and 34-36) designed as templates for the synthesis of TASP molecules.
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Earnest, I., Kalvoda, J., Francotte, E., Rihs, G., Fritz, H., Blommers, M. J. J., Raschdorf, F., Sigel, C., & Mutter, M. (1993). Template-Assembled Synthetic Proteins (TASP). Cyclic Templates with Incorporated Turn-Inducing Mimics. Helvetica Chimica Acta, 76(4), 1539–1563. https://doi.org/10.1002/hlca.19930760414
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1993
76
4
1539
1563
REVIEWED
EPFL