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conference paper
Total chemical synthesis, characterization and immunological properties of a MHC class I model using the TASP concept for protein de novo design
1993
Peptides 1992, Proceedings of the European Peptide Symposium, 22nd
The authors have recently focused on the design of TASP mols. of 4a-helix bundle topol., in which antigenic helical segments of protein surface domains are assembled on suitable templates. Here, in a first approach, the native sequence 58-74 of the a1 heavy chain domain of HLA-A2 was modeled in order to increase helix stability and amphiphilicity of the 17-mer peptide, preserving the residues for pot. T-cell receptor binding properties. [on SciFinder (R)]
Type
conference paper
Authors
Publication date
1993
Published in
Peptides 1992, Proceedings of the European Peptide Symposium, 22nd
Start page
848
End page
9
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 9, 2006
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