A double-stage feedback control structure for a double-stage mechanical system, with a single optical metrology is developed to reach the nanometer accuracy at high bandwidth over large displacements. A piezoelectric stack actuator is used for fine positioning, while a permanent magnet (PM) stepper motor handles the coarse positioning. Two different control approaches are compared to drive the PM stepper motor, while a classical PID controller is designed to drive the piezoelectric actuator. Since only a single measurement device is used, the references for both control loops (fine and coarse) must be suitably obtained. An adequate control structure including a partial observer is designed so as to take into account the influence of the fine actuator on the position estimation of the coarse actuator. The complete control mechanism and strategy ensure the tracking of the real reference with sufficient accuracy and bandwidth.