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research article
Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin
Cisplatin, CiS-[PtCl2(NH3)(2)], is known to bind to human serum transferrin, but the binding site remains a matter of some debate. Electrospray ionisation mass spectrometry has been used to characterise the interaction of cisplatin with transferrin. The studies indicate that cisplatin initially docks with, and subsequently bonds covalently to, the hydroxyl functional group of threonine 457, with the loss of HCl affording a transferrin-O-PtCl(NH3)(2) adduct. Copyright (C) 2002 John Wiley Sons, Ltd.
Type
research article
Web of Science ID
WOS:000175539300006
Authors
Publication date
2002
Published in
Volume
16
Issue
10
Start page
933
End page
935
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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