Loading...
research article
New 1-amino-1-deoxy- and 2-amino-2-deoxy-polyhydroxyazepanes: synthesis and inhibition of glycosidases
Eight new seven-membered ring iminoalditols, displaying an amino group and a hydroxymethyl group on the ring, have been synthesized from D-arabinose via epoxidation of a protected azacycloheptene and subsequent nucleophilic opening. Three of them show a potent glycosidase inhibition on amyloglucosidase and, to a lesser extend, on alpha-L-fucosidase. (C) 2004 Elsevier Ltd. All rights reserved.
Type
research article
Web of Science ID
WOS:000227002600005
Authors
Publication date
2005
Published in
Volume
16
Issue
2
Start page
313
End page
319
Note
Ecole Normale Super, Dept Chim, UMR 8642, F-75231 Paris 05, France. Swiss Fed Inst Technol, EPFL, BCH, Lab Glycochim & Synth Asymetr, CH-1015 Lausanne, Switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
Use this identifier to reference this record