The synthesis of disaccharides, oligosaccharides and analogues containing thiosugars
Disaccharide and oligosaccharide mimics are potentially more selective glycosidases inhibitors than simple monosaccharide mimics. They represent also more selective ligands for lectins and oligosaccharide receptors and can become immunostimulating agents. The biological properties of disaccharide and oligosaccharide analogs containing thiosugars (5-thiopyranoses, 4-thiofuranoses) are revised together with the methods for their obtention.
Keywords: Endo-alpha-mannosidase ; medicine salacia-reticulata ; sulfonium sulfate ; structure ; n-linked oligosaccharides ; lewis-x le(x) ; biological-activity ; glycosidase inhibitors ; conformational-analysis ; potential inhibitors ; 2'-deoxy-4'-thiopyrimidine nucleosides
Univ Sevilla, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain. Ecole Polytech Fed Lausanne, Inst Sci Mol, BCH, CH-1015 Lausanne, Switzerland.
Record created on 2005-11-09, modified on 2016-08-08