Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages catalyzed by glycosidases. Monosaccharide and disaccharide mimics such as carbasugars, iminosugars and C-linked disaccharides can be glycosidase or glycosyltransferase inhibitors. They are leads as new drugs to treat infective diseases and cancer. The preparation of a conduramine, a pentahydroxyindolizidine, and two C-linked disaccharides are outlined.
Type
research article
Authors
Publication date
2001
Published in
Volume
55
Issue
4
Start page
359
End page
365
Subjects
Note
Univ Lausanne, BCH, Chim Sect, CH-1015 Lausanne, Switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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