research article
Total asymmetric synthesis of seco-acids of 9,12-anhydroerythronolide aglycons
1998
The Diels-Alder adduct of 2,4-dimethylfuran to 1-cyanovinyl (1'S)-camphanate was converted into (2R,3R,4S,5S,6R,7R)-3,6-epoxy-4,5-isopropylidenedioxy-2,4,6-trimethyl-7- [(tert-butyl)-dimethylsilyloxy]non-1-yl phenyl sulfoxides (6), the condensation of which with (3R,4S,5R,6S)-7-benzyloxy-3,5-isopropylidenedioxy-4,6-dimethylheptan-2-o ne (7) led to the partially-protected seco-acid of the 9,12-anhydroerythronolide aglycon (5). (C) 1998 Elsevier Science Ltd. All rights reserved.
Type
research article
Author(s)
Date Issued
1998
Publisher
Published in
Volume
39
Issue
23
Start page
4039
End page
4042
Note
Univ Lausanne, Chim Sect, BCH, CH-1015 Lausanne, Switzerland.
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
November 9, 2005
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