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research article
Synthesis of (-)-6-(3'-Aminopropyloxy)Methyl-4-Demethoxy-6,7-Dideoxy-Daunomycinon, a New DNA Intercalator Related to Anthracyclines
The hydrochloride of (-)-(8R)-8-acetyl-7,8,9,10-tetrahydro-6, 8-dihydroxy-11-[3'-aminopropyloxy)methyl]naphthacene-5, 12-dione was derived from 1-(dimethaxymethyl)-2,3,5,6-tetramethylidene-7-oxabicyclo[2.2.2] heptane and shown to be a moderate intercalator of calf thymus DNA type XV.
Type
research article
Authors
Publication date
1995
Published in
Volume
5
Issue
6
Start page
547
End page
550
Note
Univ lausanne,bch dorigny,chim sect,ch-1015 lausanne,switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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