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research article
Enantioselective Synthesis of (R)-(-)-2-Acetyl-2,5,12-Trihydro-1,2,3,4-Tetrahydro-6,11-Naphthacenequin One Via Diastereoselective Diels-Alder Cycloaddition
1993
The BF3.Et2O-promoted Diels-Alder addition of 1-acetylvinyl (1'R,5'S,7'R)-3'-ethyl-2'-oxo-3'-aza-6',8'-dioxabicyclo[3.2.1]octane-7'- carboxylate (1-acetylvinylRADO(Et)) to 1-(dimethocymethyl)-2,3,5,6-tetramethylidene-7-oxabicyclo[2.2.1]heptane was highly regio-, stereo and diastereoselective giving a monoadduct that was converted into (R)-(-)4-demethoxy-7-deoxydaunomycinone.
Type
research article
Authors
Publication date
1993
Published in
Volume
34
Issue
6
Start page
1013
End page
1016
Note
Univ lausanne,chim sect,2 rue barre,ch-1005 lausanne,switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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