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research article
An expeditious, non-iterative, and asymmetric synthesis of 3,5,7,9,11,13,15-heptahydroxypentadecanals
Ozonolysis of (1R,1'R,6R,6'R)-3,3'-methylenebis{6-[(benzyloxy)methoxy]cyclohept-3-en-1 -ol} followed by the diastereo-selective reduction of the resulting beta-hydroxy ketone intermediates gives a rapid route to long-chain polyketides bearing unsymmetrical functions at their terminal positions. These can easily be converted into enantiomerically pure long-chain 1,3-polyol fragments. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
Type
research article
Web of Science ID
WOS:000184500800026
Authors
Publication date
2003
Published in
Issue
15
Start page
2959
End page
2963
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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