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research article
Total asymmetric synthesis of a new 9,12-anhydroerythronolide aglycone
Two novel, potentially antimicrobial erythronolide aglycon analogs ((-)-9 and (-)-30, respectively), which incorporate a large number of contiguous stereogenic centers, have been prepared by multistep synthesis from simple chirons. The chemistry presented demonstrates the power of the so-called 'naked sugars of the second acneration' approach. As for the sporeamicins, our macrolides are 9,12-anhydroerythronotides, yet presenting a higher degree of complexity due to additional functional groups.
Type
research article
Web of Science ID
WOS:000174340100002
Authors
Publication date
2002
Published in
Volume
85
Issue
2
Start page
417
End page
430
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 9, 2005
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