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research article
The Micro Liquid/Liquid Interface as a Transducer for Creatinine Assay
1995
Facilitated ammonium ion transfer reactions, using the crown ether dibenzo-18-crown-6, at a single microhole supported water/1,2-dichloroethane interface were used as the transducer to detect the biomolecule creatinine. The ammonium ion was produced during the enzymatic action of creatinine deiminase on creatinine. A prototype sensing device incorporating a Teflon gas permeable membrane, to exclude possible interferents, yielded a linear amperometric response to added creatinine from 20 uM to 1 mM. This range is sufficient for that required for the determination of creatinine in serum.
Type
research article
Authors
Publication date
1995
Published in
Volume
117
Issue
3-4
Start page
175
End page
185
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 7, 2005
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