The present study analyzes the uncertainty induced by the use of different state-of-the-art climate models on the prediction of climate change impacts on the runoff regimes of 11 mountainous catchments in the Swiss Alps having current glaciation rates between 0 and 50 %. The analyzed climate change scenarios are the result of 19 Regional Climate Model (RCM) runs obtained for the period 2070 – 2099 based on two different green house gas emission scenarios (the A2 and B2 scenarios defined by the Intergovernmental Panel on Climate Change) and on three different coupled Atmosphere-Ocean General Circulation Models (AOGCMs) called HadCM3, ECHAM4/OPYC3 and ARPEGE/OPA. The hydrological response of the studied catchments to the climate scenarios is simulated through a conceptual reservoir-based precipitation-runoff transformation model called GSM-SOCONT. For the glacierized catchments, the glacier surface corresponding to these future scenarios is updated through a conceptual glacier surface evolution model. The obtained results show that all climate change scenarios induce in all catchments an earlier start of the snowmelt period leading to a shift of the hydrological regimes and of the maximum monthly discharges. The mean annual runoff undergoes in most cases a significant decrease. For the glacierized catchments, the simulated regime modifications are mainly due to the increase of the mean temperature and corresponding impacts on the snow accumulation and melting processes. The hydrological regime of the catchments located at lower altitudes is more strongly affected by the changes of the seasonal precipitation. For a given emission scenario, the simulated regime modifications of all catchments are highly variable for the different RCM runs. This variability is induced by the driving AOGCM but also to a large part by the inter-RCM variability. The differences between the different RCM runs is so important that the predicted climate change impacts for the two emission scenarios A2 and B2 are overlapping.