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research article
Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers
Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.
Type
research article
Authors
Publication date
2002
Published in
Volume
41
Issue
8
Start page
1339
End page
1343
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 7, 2005
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