Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.


Published in:
Angewandte Chemie - International Edition, 41, 8, 1339-1343
Year:
2002
Laboratories:




 Record created 2005-07-07, last modified 2018-03-17


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