Journal article

Water-soluble stimuli-responsive vesicles from peptide-based diblock copolymers

Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadieneb-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.


    • LP-ARTICLE-2002-002

    Record created on 2005-07-07, modified on 2017-05-10


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