Highly branched poly(L-lysine)
This paper describes the synthesis of several novel water-soluble highly branched polypeptides. The synthesis starts with the ring-opening polymerization of ε-benzyloxycarbonyl-L-lysine N-carboxyanhydride (Z-Lys NCA) or ε-trifluoroacetyl-L-lysine N-carboxyanhydride (TFA-Lys NCA), followed by end functionalization of the peptide chain with primary amine groups that can initiate the polymerization of a second generation of branches. Repetition of this ring-opening polymerization-end functionalization sequence affords highly branched poly(ε-benzyloxycarbonyl-L-lysine) (poly(Z-Lys)) and poly(ε-trifluoroacetyl-L-lysine) (poly(TFA-Lys)) in a small number of straightforward synthetic steps. Removal of the side-chain protective groups yields water-soluble and highly branched poly(L-lysine)s, which may be of potential interest for a variety of medical applications.
Record created on 2005-07-07, modified on 2016-08-08