Peptide/protein hybrid materials: Enhanced control of structure and improved performance through conjugation of biological and synthetic polymers

The conjugation of peptides/proteins and synthetic polymers is a useful strategy to overcome some of the limitations related to the use of the individual components. This review will highlight two aspects: enhanced structural control at the nanometer level and improved performance, in particular with respect to biomedical applications. In the former case, peptide sequences are mainly used to mediate self-assembly of synthetic polymers. In the latter case, conjugation of an appropriate synthetic polymer to a pharmaceutically active peptide/protein can, for example, prevent premature enzymatic degradation and enhance blood circulation times, which is therapeutically advantageous.


Published in:
Macromolecular Bioscience, 4, 4, 383-398
Year:
2004
Other identifiers:
Scopus: 2-s2.0-4544230234
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 Record created 2005-07-07, last modified 2018-03-17


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