Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep
Schulze, Katja; Koch, Annette; Schöpf, Bernhard; Petri, Alke; Steitz, Benedikt; Chastellain, Mathieu; Hofmann, Margarethe; Hofmann, Heinrich; von Rechenberg, Brigitte
2005
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Abstract

A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammatory joint diseases. They were injected either intraarticularly or periarticularly and their uptake by cells of the synovial membrane was evaluated. Uptake was completed in 48 h and was enforced by an extracorporally applied magnet.

Details

Title Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep
Author(s) Schulze, Katja ; Koch, Annette ; Schöpf, Bernhard ; Petri, Alke ; Steitz, Benedikt ; Chastellain, Mathieu ; Hofmann, Margarethe ; Hofmann, Heinrich ; von Rechenberg, Brigitte
Published in Journal of Magnetism and Magnetic Materials
Volume 293
Issue 1
Pages 419-432
Date 2005
Keywords
DOI https://doi.org/10.1016/j.jmmm.2005.02.075
Other identifier(s) View record in Web of Science
DAR: 6947
Laboratories LTP
Record Appears in Scientific production and competences > STI - School of Engineering > IMX - Institute of Materials > LTP - Powder Technology Laboratory
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2005-04-20

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