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data paper

Normative volumes and relaxation times at 3T during brain development

Romascano, David
•
Piredda, Gian Franco
•
Caneschi, Samuele  
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April 25, 2024
Scientific Data

While research has unveiled and quantified brain markers of abnormal neurodevelopment, clinicians still work with qualitative metrics for MRI brain investigation. The purpose of the current article is to bridge the knowledge gap between case-control cohort studies and individual patient care. Here, we provide a unique dataset of seventy-three 3-to-17 years-old healthy subjects acquired with a 6-minute MRI protocol encompassing T1 and T2 relaxation quantitative sequence that can be readily implemented in the clinical setting; MP2RAGE for T1 mapping and the prototype sequence GRAPPATINI for T2 mapping. White matter and grey matter volumes were automatically quantified. We further provide normative developmental curves based on these two imaging sequences; T1, T2 and volume normative ranges with respect to age were computed, for each ROI of a pediatric brain atlas. This open-source dataset provides normative values allowing to position individual patients acquired with the same protocol on the brain maturation curve and as such provides potentially useful quantitative biomarkers facilitating precise and personalized care.

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Type
data paper
DOI
10.1038/s41597-024-03267-3
Web of Science ID

WOS:001233892400001

Author(s)
Romascano, David
Piredda, Gian Franco
Caneschi, Samuele  
Hilbert, Tom  
Ledoux, Jean-Baptiste
Marechal, Benedicte  
Corredor, Ricardo  
Kober, Tobias  
Fornari, Eleonora
Hagmann, Patric
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Date Issued

2024-04-25

Publisher

Nature Portfolio

Published in
Scientific Data
Volume

11

Issue

1

Start page

429

Subjects

Mri

•

Networks

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
EPFL  
FunderGrant Number

Societe Academique Vaudoise

Prepared Adult Initiative

Logival Society

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Available on Infoscience
June 19, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/208667
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