Loading...
research article
Metabolically enhanced CAR T cells efficiently clear solid tumors in mice
January 2, 2024
Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.
Type
research article
Web of Science ID
WOS:001138166100019
Authors
Publication date
2024-01-02
Publisher
Published in
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 21, 2024
Use this identifier to reference this record